diff --git a/.github/workflows/ci.yml b/.github/workflows/ci.yml
index 77245293..c66dd292 100644
--- a/.github/workflows/ci.yml
+++ b/.github/workflows/ci.yml
@@ -35,50 +35,82 @@ jobs:
         run: nox -s fmt-rust
 
   clippy:
-    if: github.ref != 'refs/heads/main'
-    runs-on: ubuntu-latest
-    steps:
-      - uses: actions/checkout@v3
-      - uses: actions/setup-python@v4
-      - run: pip install nox
-      - uses: dtolnay/rust-toolchain@stable
-        with:
-          components: clippy
-      - run: nox -s clippy
-
-  check-target:
     needs: [fmt]
-    runs-on: ubuntu-latest
-    if: ${{ github.event_name != 'pull_request' && github.ref != 'refs/heads/main' }}
+    runs-on: ${{ matrix.platform.os }}
+    if: github.ref != 'refs/heads/main'
     strategy:
       # If one platform fails, allow the rest to keep testing if `CI-no-fail-fast` label is present
       fail-fast: ${{ !contains(github.event.pull_request.labels.*.name, 'CI-no-fail-fast') }}
       matrix:
-        target: [powerpc64le-unknown-linux-gnu, s390x-unknown-linux-gnu, wasm32-wasi]
-    name: check-${{ matrix.target }}
+        rust: [stable]
+        platform: [
+          {
+            os: "macos-latest",
+            python-architecture: "x64",
+            rust-target: "x86_64-apple-darwin",
+          },
+          {
+            os: "ubuntu-latest",
+            python-architecture: "x64",
+            rust-target: "x86_64-unknown-linux-gnu",
+          },
+          {
+            os: "ubuntu-latest",
+            python-architecture: "x64",
+            rust-target: "powerpc64le-unknown-linux-gnu",
+          },
+          {
+            os: "ubuntu-latest",
+            python-architecture: "x64",
+            rust-target: "s390x-unknown-linux-gnu",
+          },
+          {
+            os: "ubuntu-latest",
+            python-architecture: "x64",
+            rust-target: "wasm32-wasi",
+          },
+          {
+            os: "windows-latest",
+            python-architecture: "x64",
+            rust-target: "x86_64-pc-windows-msvc",
+          },
+          {
+            os: "windows-latest",
+            python-architecture: "x86",
+            rust-target: "i686-pc-windows-msvc",
+          },
+        ]
+        include:
+          - rust: 1.48.0
+            python-version: "3.11"
+            platform:
+              {
+                os: "ubuntu-latest",
+                python-architecture: "x64",
+                rust-target: "x86_64-unknown-linux-gnu",
+              }
+            msrv: "MSRV"
+    name: clippy/${{ matrix.platform.rust-target }}/${{ matrix.rust }}
     steps:
       - uses: actions/checkout@v3
-      - name: Install Rust toolchain
-        uses: dtolnay/rust-toolchain@stable
+      - uses: dtolnay/rust-toolchain@master
         with:
-          targets: ${{ matrix.target }}
-      - name: Run cargo checks
-        run: |
-          set -x
-          VERSIONS=("3.7" "3.8" "3.9" "3.10" "3.11")
-          for VERSION in ${VERSIONS[@]}; do
-            echo "version=$VERSION" > config.txt
-            echo "suppress_build_script_link_lines=true" >> config.txt
-            PYO3_BUILD_CONFIG=$(pwd)/config.txt cargo check --all-targets --no-default-features
-            PYO3_BUILD_CONFIG=$(pwd)/config.txt cargo check --all-targets --no-default-features --features "abi3"
-            PYO3_BUILD_CONFIG=$(pwd)/config.txt cargo check --all-targets --features "full multiple-pymethods"
-            PYO3_BUILD_CONFIG=$(pwd)/config.txt cargo check --all-targets --features "abi3 full multiple-pymethods"
-          done
+          toolchain: ${{ matrix.rust }}
+          targets: ${{ matrix.rust-target }}
+          components: clippy
+      - uses: actions/setup-python@v4
+        with:
+          architecture: ${{ matrix.platform.python-architecture }}
+      - run: python -m pip install nox
+      - if: matrix.msrv == 'MSRV'
+        name: Prepare minimal package versions (MSRV only)
+        run: nox -s set-minimal-package-versions
+      - run: nox -s clippy-all
 
   build-pr:
     if: github.event_name == 'pull_request'
     name: python${{ matrix.python-version }}-${{ matrix.platform.python-architecture }} ${{ matrix.platform.os }} rust-${{ matrix.rust }}
-    needs: [fmt] # don't wait for clippy as fails rarely and takes longer
+    needs: [fmt]
     uses: ./.github/workflows/build.yml
     with:
       os: ${{ matrix.platform.os }}
@@ -114,12 +146,16 @@ jobs:
               python-architecture: "x64",
               rust-target: "x86_64-pc-windows-msvc",
             },
+            {
+              os: "windows-latest",
+              python-architecture: "x86",
+              rust-target: "i686-pc-windows-msvc",
+            }
           ]
-
   build-full:
     if: ${{ github.event_name != 'pull_request' && github.ref != 'refs/heads/main' }}
     name: python${{ matrix.python-version }}-${{ matrix.platform.python-architecture }} ${{ matrix.platform.os }} rust-${{ matrix.rust }}
-    needs: [fmt] # don't wait for clippy as fails rarely and takes longer
+    needs: [fmt]
     uses: ./.github/workflows/build.yml
     with:
       os: ${{ matrix.platform.os }}
@@ -317,7 +353,6 @@ jobs:
     needs:
       - fmt
       - clippy
-      - check-target
       - build-pr
       - build-full
       - valgrind
diff --git a/benches/bench_intern.rs b/benches/bench_intern.rs
index 927a6e6a..b70edf92 100644
--- a/benches/bench_intern.rs
+++ b/benches/bench_intern.rs
@@ -2,11 +2,9 @@ use criterion::{criterion_group, criterion_main, Bencher, Criterion};
 
 use pyo3::prelude::*;
 
-use pyo3::{intern, prepare_freethreaded_python};
+use pyo3::intern;
 
 fn getattr_direct(b: &mut Bencher<'_>) {
-    prepare_freethreaded_python();
-
     Python::with_gil(|py| {
         let sys = py.import("sys").unwrap();
 
@@ -15,8 +13,6 @@ fn getattr_direct(b: &mut Bencher<'_>) {
 }
 
 fn getattr_intern(b: &mut Bencher<'_>) {
-    prepare_freethreaded_python();
-
     Python::with_gil(|py| {
         let sys = py.import("sys").unwrap();
 
diff --git a/benches/bench_tuple.rs b/benches/bench_tuple.rs
index 4a820638..4c419655 100644
--- a/benches/bench_tuple.rs
+++ b/benches/bench_tuple.rs
@@ -37,7 +37,7 @@ fn tuple_get_item(b: &mut Bencher<'_>) {
     });
 }
 
-#[cfg(not(Py_LIMITED_API))]
+#[cfg(not(any(Py_LIMITED_API, PyPy)))]
 fn tuple_get_item_unchecked(b: &mut Bencher<'_>) {
     Python::with_gil(|py| {
         const LEN: usize = 50_000;
@@ -57,7 +57,7 @@ fn criterion_benchmark(c: &mut Criterion) {
     c.bench_function("iter_tuple", iter_tuple);
     c.bench_function("tuple_new", tuple_new);
     c.bench_function("tuple_get_item", tuple_get_item);
-    #[cfg(not(Py_LIMITED_API))]
+    #[cfg(not(any(Py_LIMITED_API, PyPy)))]
     c.bench_function("tuple_get_item_unchecked", tuple_get_item_unchecked);
 }
 
diff --git a/newsfragments/2826.added.md b/newsfragments/2826.added.md
new file mode 100644
index 00000000..4bd084ae
--- /dev/null
+++ b/newsfragments/2826.added.md
@@ -0,0 +1 @@
+Add `PyList::get_item_unchecked` for PyPy.
diff --git a/noxfile.py b/noxfile.py
index a397311f..0a0b0b73 100644
--- a/noxfile.py
+++ b/noxfile.py
@@ -5,9 +5,10 @@ import subprocess
 import sys
 import tempfile
 import time
+from functools import lru_cache
 from glob import glob
 from pathlib import Path
-from typing import Any, Dict, List, Optional
+from typing import Any, Dict, List, Optional, Tuple
 
 import nox
 
@@ -15,6 +16,8 @@ nox.options.sessions = ["test", "clippy", "fmt"]
 
 
 PYO3_DIR = Path(__file__).parent
+PY_VERSIONS = ("3.7", "3.8", "3.9", "3.10", "3.11")
+PYPY_VERSIONS = ("3.7", "3.8", "3.9")
 
 
 @nox.session(venv_backend="none")
@@ -83,20 +86,71 @@ def fmt_py(session: nox.Session):
     _run(session, "black", ".", "--check")
 
 
-@nox.session(venv_backend="none")
-def clippy(session: nox.Session) -> None:
-    for feature_set in ["full", "abi3 full"]:
-        _run(
-            session,
-            "cargo",
-            "clippy",
-            f"--features={feature_set}",
-            "--all-targets",
-            "--workspace",
-            "--",
-            "--deny=warnings",
-            external=True,
-        )
+@nox.session(name="clippy", venv_backend="none")
+def clippy(session: nox.Session) -> bool:
+    if not _clippy(session):
+        session.error("one or more jobs failed")
+
+
+def _clippy(session: nox.Session, *, env: Dict[str, str] = None) -> bool:
+    success = True
+    env = env or os.environ
+    for feature_set in _get_feature_sets():
+        command = "clippy"
+        extra = ("--", "--deny=warnings")
+        if _get_rust_version()[:2] == (1, 48):
+            # 1.48 crashes during clippy because of lints requested
+            # in .cargo/config
+            command = "check"
+            extra = ()
+        try:
+            _run(
+                session,
+                "cargo",
+                command,
+                *feature_set,
+                "--all-targets",
+                "--workspace",
+                *extra,
+                external=True,
+                env=env,
+            )
+        except Exception:
+            success = False
+    return success
+
+
+@nox.session(name="clippy-all", venv_backend="none")
+def clippy_all(session: nox.Session) -> None:
+    success = True
+    with tempfile.NamedTemporaryFile("r+") as config:
+        env = os.environ.copy()
+        env["PYO3_CONFIG_FILE"] = config.name
+        env["PYO3_CI"] = "1"
+
+        def _clippy_with_config(implementation, version) -> bool:
+            config.seek(0)
+            config.truncate(0)
+            config.write(
+                f"""\
+implementation={implementation}
+version={version}
+suppress_build_script_link_lines=true
+"""
+            )
+            config.flush()
+
+            session.log(f"{implementation} {version}")
+            return _clippy(session, env=env)
+
+        for version in PY_VERSIONS:
+            success &= _clippy_with_config("CPython", version)
+
+        for version in PYPY_VERSIONS:
+            success &= _clippy_with_config("PyPy", version)
+
+    if not success:
+        session.error("one or more jobs failed")
 
 
 @nox.session(venv_backend="none")
@@ -396,14 +450,56 @@ def set_minimal_package_versions(session: nox.Session):
     _run(session, "cargo", "metadata", silent=True, external=True)
 
 
-def _get_rust_target() -> str:
+@lru_cache()
+def _get_rust_info() -> Tuple[str, ...]:
     output = _get_output("rustc", "-vV")
 
-    for line in output.splitlines():
+    return tuple(output.splitlines())
+
+
+def _get_rust_version() -> Tuple[int, int, int, List[str]]:
+    for line in _get_rust_info():
+        if line.startswith(_RELEASE_LINE_START):
+            version = line[len(_RELEASE_LINE_START) :].strip()
+            # e.g. 1.67.0-beta.2
+            (version_number, *extra) = version.split("-", maxsplit=1)
+            return (*map(int, version_number.split(".")), extra)
+
+
+def _get_rust_target() -> str:
+    for line in _get_rust_info():
         if line.startswith(_HOST_LINE_START):
             return line[len(_HOST_LINE_START) :].strip()
 
 
+@lru_cache()
+def _get_feature_sets() -> Tuple[Tuple[str, ...], ...]:
+    """Returns feature sets to use for clippy job"""
+    rust_version = _get_rust_version()
+    if rust_version[:2] >= (1, 62):
+        # multiple-pymethods feature not supported before 1.62
+        return (
+            ("--no-default-features",),
+            (
+                "--no-default-features",
+                "--features=abi3",
+            ),
+            ("--features=full multiple-pymethods",),
+            ("--features=abi3 full multiple-pymethods",),
+        )
+    else:
+        return (
+            ("--no-default-features",),
+            (
+                "--no-default-features",
+                "--features=abi3",
+            ),
+            ("--features=full",),
+            ("--features=abi3 full",),
+        )
+
+
+_RELEASE_LINE_START = "release: "
 _HOST_LINE_START = "host: "