diff --git a/CHANGELOG.md b/CHANGELOG.md
index 39cddd34..dc084010 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -37,6 +37,7 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0
 - Fix case where `ValueError` without message could be raised by the `#[derive(FromPyObject)]` generated implementation for a tuple struct. [#2414](https://github.com/PyO3/pyo3/pull/2414)
 - Fix compile failure when using `#[pyo3(from_py_with = "pouf")]` in on a field in a `#[derive(FromPyObject)]` struct. [#2414](https://github.com/PyO3/pyo3/pull/2414)
 - Fix FFI definitions `_PyDateTime_BaseTime` lacking leading underscores in their names. [#2421](https://github.com/PyO3/pyo3/pull/2421)
+- Remove FFI definition `PyArena` on Python 3.10 and up. [#2421](https://github.com/PyO3/pyo3/pull/2421)
 
 ## [0.16.5] - 2022-05-15
 
diff --git a/pyo3-ffi/src/lib.rs b/pyo3-ffi/src/lib.rs
index 9eabd846..7033c37e 100644
--- a/pyo3-ffi/src/lib.rs
+++ b/pyo3-ffi/src/lib.rs
@@ -316,7 +316,7 @@ pub use self::moduleobject::*;
 pub use self::object::*;
 pub use self::objimpl::*;
 pub use self::osmodule::*;
-#[cfg(not(Py_LIMITED_API))]
+#[cfg(not(any(Py_LIMITED_API, Py_3_10)))]
 pub use self::pyarena::*;
 pub use self::pycapsule::*;
 pub use self::pyerrors::*;
@@ -399,7 +399,7 @@ mod osmodule;
 // skipped picklebufobject.h
 // skipped pyctype.h
 // skipped py_curses.h
-#[cfg(not(Py_LIMITED_API))]
+#[cfg(not(any(Py_LIMITED_API, Py_3_10)))]
 mod pyarena;
 mod pycapsule;
 // skipped pydecimal.h
diff --git a/src/marker.rs b/src/marker.rs
index 79b5489f..6c27833b 100644
--- a/src/marker.rs
+++ b/src/marker.rs
@@ -184,7 +184,7 @@ mod negative_impls {
     impl !Ungil for crate::ffi::PyCodeObject {}
     #[cfg(not(Py_LIMITED_API))]
     impl !Ungil for crate::ffi::PyDictKeysObject {}
-    #[cfg(not(Py_LIMITED_API))]
+    #[cfg(not(any(Py_LIMITED_API, Py_3_10)))]
     impl !Ungil for crate::ffi::PyArena {}
 }