diff --git a/newsfragments/3502.added.md b/newsfragments/3502.added.md
new file mode 100644
index 00000000..12109174
--- /dev/null
+++ b/newsfragments/3502.added.md
@@ -0,0 +1 @@
+Added the `PyInterpreterConfig` struct, its constants and `Py_NewInterpreterFromConfig`.
\ No newline at end of file
diff --git a/pyo3-ffi/src/cpython/pylifecycle.rs b/pyo3-ffi/src/cpython/pylifecycle.rs
index 08c47881..c259c369 100644
--- a/pyo3-ffi/src/cpython/pylifecycle.rs
+++ b/pyo3-ffi/src/cpython/pylifecycle.rs
@@ -44,5 +44,56 @@ extern "C" {
     // skipped _Py_LegacyLocaleDetected
     // skipped _Py_SetLocaleFromEnv
 
-    // skipped _Py_NewInterpreter
 }
+
+#[cfg(Py_3_12)]
+pub const PyInterpreterConfig_DEFAULT_GIL: c_int = 0;
+#[cfg(Py_3_12)]
+pub const PyInterpreterConfig_SHARED_GIL: c_int = 1;
+#[cfg(Py_3_12)]
+pub const PyInterpreterConfig_OWN_GIL: c_int = 2;
+
+#[cfg(Py_3_12)]
+#[repr(C)]
+pub struct PyInterpreterConfig {
+    pub use_main_obmalloc: c_int,
+    pub allow_fork: c_int,
+    pub allow_exec: c_int,
+    pub allow_threads: c_int,
+    pub allow_daemon_threads: c_int,
+    pub check_multi_interp_extensions: c_int,
+    pub gil: c_int,
+}
+
+#[cfg(Py_3_12)]
+pub const _PyInterpreterConfig_INIT: PyInterpreterConfig = PyInterpreterConfig {
+    use_main_obmalloc: 0,
+    allow_fork: 0,
+    allow_exec: 0,
+    allow_threads: 1,
+    allow_daemon_threads: 0,
+    check_multi_interp_extensions: 1,
+    gil: PyInterpreterConfig_OWN_GIL,
+};
+
+#[cfg(Py_3_12)]
+pub const _PyInterpreterConfig_LEGACY_INIT: PyInterpreterConfig = PyInterpreterConfig {
+    use_main_obmalloc: 1,
+    allow_fork: 1,
+    allow_exec: 1,
+    allow_threads: 1,
+    allow_daemon_threads: 1,
+    check_multi_interp_extensions: 0,
+    gil: PyInterpreterConfig_SHARED_GIL,
+};
+
+extern "C" {
+    #[cfg(Py_3_12)]
+    pub fn Py_NewInterpreterFromConfig(
+        tstate_p: *mut *mut crate::PyThreadState,
+        config: *const PyInterpreterConfig,
+    ) -> PyStatus;
+}
+
+// skipped atexit_datacallbackfunc
+// skipped _Py_AtExit